THE SYNAPTIC VESICLE CYCLE - A CASCADE OF PROTEIN-PROTEIN INTERACTIONS

被引：1769
作者：
SUDHOF, TC [1 ]
机构：
[1] UNIV TEXAS,HLTH SCI CTR,SW MED SCH,HOWARD HUGHES MED INST,DALLAS,TX 75235
来源：
NATURE | 1995年 / 375卷 / 6533期
关键词：
D O I：
10.1038/375645a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The synaptic vesicle cycle at the nerve terminal consists of vesicle exocytosis with neurotransmitter release, endocytosis of empty vesicles, and regeneration of fresh vesicles. Of all cellular transport pathways, the synaptic vesicle cycle is the fastest and the most tightly regulated. A convergence of results now allows formulation of molecular models for key steps of the cycle. These developments may form the basis for a mechanistic understanding of higher neural function.
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页码：645 / 653
页数：9
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