DNA HELICASES - ENZYMES WITH ESSENTIAL ROLES IN ALL ASPECTS OF DNA METABOLISM

被引：269

作者：

MATSON, SW ^{[1
]}

BEAN, DW ^{[1
]}

GEORGE, JW ^{[1
]}

机构：

[1] UNIV N CAROLINA, DEPT BIOL, CHAPEL HILL, NC 27599 USA

来源：

BIOESSAYS | 1994年 / 16卷 / 01期

关键词：

D O I：

10.1002/bies.950160103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA helicases catalyze the disruption of the hydrogen bonds that hold the two strands of double-stranded DNA together. This energy-requiring unwinding reaction results in the formation of the single-stranded DNA required as a template or reaction intermediate in DNA replication, repair and recombination. A combination of biochemical and genetic studies have been used to probe and define the roles of the multiple DNA helicases found in E. coli. This work and similar efforts in eukaryotic cells, although far from complete, have established that DNA helicases are essential components of the machinery that interacts with the DNA molecule.

引用

页码：13 / 22

页数：10

共 79 条

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