COOPERATIVE INTERACTION BETWEEN C-MYC AND BCL-2 PROTOONCOGENES

被引：751

作者：

FANIDI, A ^{[1
]}

HARRINGTON, EA ^{[1
]}

EVAN, GI ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND, BIOCHEM CELL NUCLEUS LAB, 44 LINCOLNS INN FIELDS, LONDON WC2A 3PX, ENGLAND

来源：

NATURE | 1992年 / 359卷 / 6395期

关键词：

D O I：

10.1038/359554a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THE bcl-2 proto-oncogene is activated by translocation in a variety of B-lymphoid tumours and synergizes with the c-myc oncogene in tumour progression1. The mechanism of synergy is unclear but bcl-2 expression inhibits apoptosis2-6, a property presumably pertinent to its proto-oncogenic mode of action4. We have shown that the c-myc gene is a potent inducer of apoptosis, in addition to its established role in mitogenesis7. Here we show that expression of the bcl-2 protein, Bcl-2, specifically abrogates c-myc-induced apoptosis without affecting the c-myc mitogenic function. This provides a novel mechanism for oncogene cooperation, of potential importance both in carcinogenesis and in the evolution of drug resistance in tumours.

引用

页码：554 / 556

页数：3

共 16 条

[1]

ASKEW DS, 1991, ONCOGENE, V6, P1915

[2] THE BIOCHEMISTRY OF CELL-DEATH BY APOPTOSIS [J].