SYNTHESIS OF HOMOCHIRAL POTASSIUM CHANNEL OPENERS - ROLE OF THE BENZOPYRANYL 3-HYDROXYL GROUP IN CROMAKALIM AND PYRIDINE N-OXIDES IN DETERMINING THE BIOLOGICAL-ACTIVITIES OF ENANTIOMERS

被引：8

作者：

ATTWOOD, MR

BROWN, BS

DUNSDON, RM

HURST, DN

JONES, PS

KAY, PB

机构：

[1] Roche Products Limited, Welwyn Garden City

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)81070-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of several homochiral benzopyranyl potassium channel openers is described. A subtle stereochemical effect of the 3-hydroxyl group on the biological activities of the enantiomers was observed.

引用

页码：229 / 234

页数：6

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