Pediatric medulloblastoma update on molecular classification driving targeted therapies

被引：60

作者：

DeSouza, Ruth-Mary ^{[1
]}

Jones, Benjamin R. T. ^{[2
]}

Lowis, Stephen P. ^{[3
]}

Kurian, Kathreena M. ^{[4
]}

机构：

[1] Kings Coll Hosp London, Neurosurg, London, England

[2] Royal Bolton Hosp, Bolton, England

[3] Univ Bristol, BMT Oncol, Bristol, Avon, England

[4] Univ Bristol, Inst Clin Neurosci, Brain Tumour Grp, Bristol, Avon, England

来源：

FRONTIERS IN ONCOLOGY | 2014年 / 4卷

关键词：

pediatric; medulloblastoma; molecular; therapies; classification;

D O I：

10.3389/fonc.2014.00176

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As advances in the molecular and genetic profiling of pediatric medulloblastoma evolve, associations with prognosis and treatment are found (prognostic and predictive biomarkers) and research is directed at molecular therapies. Medulloblastoma typically affects young patients, where the implications of any treatment on the developing brain must be carefully considered. The aim of this article is to provide a clear comprehensible update on the role molecular profiling and subgroups in pediatric medulloblastoma as it is likely to contribute significantly toward prognostication. Knowledge of this classification is of particular interest because there are new molecular therapies targeting the Shh subgroup of medulloblastomas.

引用

页数：8

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