Effective methods of synthesis of 2-hetaryl-[1,2,4] triazolo[1,5-c] qinazolin-5(6H)-ones and their antibacterial activity

被引：0
作者：
Biliy, A. K. [1 ]
Kovalenko, S. I. [1 ]
Kamishniy, O. M. [2 ]
Polishchuk, N. M. [3 ]
机构：
[1] Zaporizhzhya State Med Univ, Organ & Bioorgan Chem, Zaporizhia, Ukraine
[2] Zaporizhzhya State Med Univ, Med, Microbiol Virol & Immunol, Zaporizhia, Ukraine
[3] Zaporizhzhya State Med Univ, Microbiol Virol & Immunol, Zaporizhia, Ukraine
来源：
ZAPOROZHYE MEDICAL JOURNAL | 2013年 / 06期
关键词：
heterocyclization; 2-(3-hetaryl-[1,2,4] triazol-5-yl) phenyl] amines; 2-hetaryl-[1,2,4] triazolo[1,5-.]-quinazolin-5(6H)-ones; antimicrobial and antifungal activity;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A number of efficient methods for the synthesis 2-hetaryl-[1,2,4] triazolo[1,5-c]-quinazolin-5(6H)-ones by the heterocyclization of [2-(3-hetaryl-[1,2,4] triazol-5-yl) phenyl] amines with N, N-carbonyldiimidazole, ethyl carbonochloridate, arylisocyanates were developed. In was shown that the most effective method for synthesis of 2-hetaryl-[1,2,4] triazolo[1,5-.]-quinazolin-5(6H)-ones is the reaction of [2-(3-hetaryl-[1,2,4] triazol-5-yl) phenyl] amines with Aryl Isocyanates. The structure of the synthesized compounds was confirmed by elemental analysis and spectroscopic methods. The results of studies of the synthesized compounds for antimicrobial and antifungal activity were showed.
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页码：83 / 87
页数：5
相关论文
共 17 条
  • [1] Aniszewski T., 2007, ALKALOIDS SECRETS LI, V1st ed.
  • [2] Armarego W. L. F., 2008, QUINAZOLINES, V24, DOI [10.1002/9780470186916.ch4, DOI 10.1002/9780470186916.CH4]
  • [3] Synthesis and evaluation of adenosine antagonist activity of a series of [1,2,4]triazolo[1,5-c]quinazolines
    Balo, Carmen
    Lopez, Carmen
    Brea, Jose Manuel
    Fernandez, Franco
    Caamano, Olga
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (03) : 372 - 375
  • [4] Biliy AK, 2013, ZAPOROZHYE MED J, P83
  • [5] Blank J, 2003, EUR J ORG CHEM, V2003, P182, DOI 10.1002/1099-0690(200301)2003:1<182::AID-EJOC182>3.0.CO
  • [6] 2-S
  • [7] SYNTHESIS OF [1,2,4]TRIAZOLOQUINAZOLINE AND [1,2,4]-TRIAZOLO-1,4-BENZODIAZEPINE DERIVATIVES
    GATTA, F
    DELGIUDICE, MR
    BORIONI, A
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1993, 30 (01) : 11 - 16
  • [8] NEW TETRACYCLIC DERIVATIVES OF IMIDAZO[1,5-A][1,4]BENZODIAZEPINES AND OF IMIDAZO[1,5-A]THIENO[3,2-F][1,4]DIAZEPINES
    GERECKE, M
    KYBURZ, E
    BORER, R
    GASSNER, W
    [J]. HETEROCYCLES, 1994, 39 (02) : 693 - 721
  • [9] An efficient and convenient synthesis of 2-thio[1,2,4]triazolo[1,5-c]quinazoline and its derivatives
    Karpenko, Alexandr V.
    Kovalenko, Sergey I.
    Shishkina, Svetlana V.
    Shishkin, Oleg V.
    [J]. MONATSHEFTE FUR CHEMIE, 2006, 137 (12): : 1543 - 1549
  • [10] KARPENKO OV, 2006, THESIS
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