Low-dose versus high-dose oxytocin augmentation of labor - A randomized trial

被引：52

作者：

Xenakis, EMJ

Langer, O

Piper, JM

Conway, D

Berkus, MD

机构：

[1] Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1995年 / 173卷 / 06期

关键词：

labor abnormalities; oxytocin; augmentation;

D O I：

10.1016/0002-9378(95)90444-1

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: Our purpose was to compare the efficacy and safety of low-dose versus high-dose oxytocin regimens in the augmentation of labor. STUDY DESIGN: Three hundred ten term pregnancies requiring augmentation of labor underwent randomization to receive either a low-dose or high-dose oxytocin augmentation regimen. Maternal demographics, labor-delivery data, and neonatal outcome were compared. RESULTS: The high-dose oxytocin group had a significantly lower cesarean section rate, regardless of parity (10.4% vs 25.7%, p < 0.001), with no differences in maternal complications and neonatal outcomes. The time needed to correct the labor abnormality was also significantly decreased (1.24 +/- 1.4 hours vs 3.12 +/- 1.6 hours, p < 0.001) in the high-dose group. CONCLUSIONS: The use of a high-dose oxytocin regimen benefits both nulliparous and multiparous women requiring labor augmentation by significantly lowering both the time necessary to correct the labor abnormality and the need for cesarean section.

引用

页码：1874 / 1878

页数：5

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