EPIDEMIOLOGY OF GENOTYPES OF HEPATITIS-C VIRUS IN JAPANESE PATIENTS WITH TYPE-C CHRONIC LIVER-DISEASES - A MULTI-INSTITUTION ANALYSIS

被引：50

作者：

TANAKA, E

KIYOSAWA, K

MATSUSHIMA, T

ISHIKAWA, K

HINO, K

TANAKA, S

NOSE, H

KUMADA, H

IINO, S

KAMIMURA, T

UNOURA, M

MIZOKAMI, M

OKANOUE, T

KUROKI, T

YAMADA, G

MIURA, T

YANO, M

TSUBOUCHI, H

KOHARA, M

SATO, S

HATTORI, N

FURUTA, S

KARINO, Y

SAINOKAMI, S

TANAKA, T

OKADA, S

CHAYAMA, K

YASUDA, K

KUWANA, K

KANEKO, S

MIZOGUCHI, N

YASUI, K

TAKEDA, T

KISHI, F

YATSUHASHI, H

MARUYAMA, T

TSUKIYAMAKOHARA, K

机构：

[1] SHINSHU UNIV,SCH MED,DEPT INTERNAL MED 2,MATSUMOTO,NAGANO 390,JAPAN

[2] HOKKAIDO UNIV,SCH MED,DEPT INTERNAL MED 3,SAPPORO,HOKKAIDO 060,JAPAN

[3] IWATE MED UNIV,DEPT INTERNAL MED 1,MORIOKA,IWATE 020,JAPAN

[4] NATL DEF MED COLL,DEPT INTERNAL MED 2,TOKOROZAWA,SAITAMA 359,JAPAN

[5] TORANOMON GEN HOSP,DEPT GASTROENTEROL,TOKYO,JAPAN

[6] TOKYO METROPOLITAN KOMAGOME HOSP,LIVER UNIT,TOKYO,JAPAN

[7] NATL CANC CTR,DEPT INTERNAL MED,TOKYO,JAPAN

[8] ST MARIANNA UNIV,SCH MED,INST MED SCI,KAWASAKI,KANAGAWA,JAPAN

[9] NIIGATA UNIV,SCH MED,DEPT INTERNAL MED 3,NIIGATA 951,JAPAN

[10] KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 1,KANAZAWA,ISHIKAWA 920,JAPAN

[11] NAGOYA CITY UNIV,SCH MED,DEPT INTERNAL MED 2,NAGOYA,AICHI 467,JAPAN

[12] KYOTO PREFECTURAL UNIV MED,DEPT INTERNAL MED 3,OSAKA,JAPAN

[13] OSAKA CITY UNIV,SCH MED,DEPT INTERNAL MED 3,OSAKA 545,JAPAN

[14] OKAYAMA UNIV,SCH MED,DEPT INTERNAL MED 1,OKAYAMA 700,JAPAN

[15] MIURA CLIN,DIV HEPATOL,KOCHI,JAPAN

[16] NAGASAKI CHUO NATL HOSP,INST CLIN RES,NAGASAKI,JAPAN

[17] MIYAZAKI MED COLL,DEPT INTERNAL MED 2,MIYAZAKI 88916,JAPAN

[18] TOKYO METROPOLITAN INST MED SCI,DEPT MICROBIOL,TOKYO 113,JAPAN

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 1995年 / 10卷 / 05期

关键词：

CHRONIC LIVER DISEASE; EPIDEMIOLOGY; GENOTYPE; HEPATITIS C VIRUS;

D O I：

10.1111/j.1440-1746.1995.tb01344.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Sixteen medical institutions in Japan collaborated in this study of the epidemiology of hepatitis C virus (HCV) genotypes. A total of 4176 patients with type C chronic liver disease, from the four main islands of Japan, were evaluated. Of those evaluated, 2794 had chronic hepatitis, 727 had liver cirrhosis and 655 had hepatocellular carcinoma. The HCV genotype of the patients was determined by an enzyme-linked immunosorbent assay based on serological genotype 1- and 2-specific recombinant peptides (SG-1 and SG-2, respectively) of the NS4 region. The prevalence of SG-1 and SG-2 HCV was similar in the four main islands of Japan. SG-1 HCV predominated in each disease category (69-76%). The percentage of patients with SG-1 HCV increased by 7%, while that of patients with SG-2 HCV decreased by 7%, as liver disease progressed in severity from chronic hepatitis to carcinoma (P < 0.001). Patients with either SG-1 or SG-2 had a similar mean age and history of blood transfusion. In conclusion, SG-1 HCV was found to predominate in Japan, and the HCV genotype was found to be related to the stage of hepatitis C disease.

引用

页码：538 / 545

页数：8

共 32 条

[1] DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS IN PROSPECTIVELY FOLLOWED TRANSFUSION RECIPIENTS WITH ACUTE AND CHRONIC NON-A-HEPATITIS, NON-B-HEPATITIS [J].