EFFECT OF ETHANOL ON CADMIUM UPTAKE AND METABOLISM OF ZINC AND COPPER IN RATS EXPOSED TO CADMIUM

被引:37
作者
SHARMA, G
SANDHIR, R
NATH, R
GILL, K
机构
[1] Department of Biochemistry, Postgraduate Institute, Medical Education/Research
关键词
CADMIUM; ETHANOL; COPPER; ZINC; RATS;
D O I
10.1093/jn/121.1.87
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Effects of chronic administration of cadmium and ethanol, alone as well as in combination, on the uptake of cadmium and its interaction with other essential trace elements in various tissues of adult rats were investigated. Cadmium given in combination with ethanol led to a pronounced increase in cadmium absorption and accumulation in all the tissues studied relative to both non-exposed controls and rats treated with cadmium alone. Both cadmium and ethanol exhibited specific effects on copper and zinc levels of the tissues. These effects often were significantly altered when the animals were co-exposed to cadmium and ethanol. The results suggested that although both cadmium and ethanol individually pose a hazard to essential trace metal homeostasis of various organs, co-exposure can pose a major threat since animals exposed to ethanol absorb much more cadmium than their unexposed counterparts.
引用
收藏
页码:87 / 91
页数:5
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