EFFECT OF CYSTEINE ON HEPATIC TOXICITY AND ANTISCHISTOSOMAL ACTIVITY OF ANTIMONYL POTASSIUM TARTRATE

被引:0
作者
SALEH, S [1 ]
KHAYYAL, MT [1 ]
机构
[1] UNIV CAIRO, FAC PHARM, DEPT PHARMACOL, CAIRO, EGYPT
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D O I
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中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Cysteine produced a significant and progressive reduction in the toxicity of antimonyl potassium tartrate (APT) when the 2 substances were injected into mice and rabbits in ratios of APT to cysteine ranging from 1:1-1:3. The reduction in toxicity was highest with the 1:3 ratio. However, the combination of the 2 substances, especially in the ratio of 1:3, appreciably reduced the antischistosomal activity of APT both in vivo and in vitro.
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页码:379 / 384
页数:6
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