FERROUS-IONS DETECTED IN IRON-OVERLOADED CORD-BLOOD PLASMA FROM PRETERM AND TERM BABIES - IMPLICATIONS FOR OXIDATIVE STRESS

被引：47

作者：

BERGER, HM

MUMBY, S

GUTTERIDGE, JMC

机构：

[1] ROYAL BROMPTON HOSP,DEPT ANAESTHESIA & INTENS CARE,OXYGEN CHEM LAB,CRIT CARE UNIT,LONDON SW3 6NP,ENGLAND

[2] LEIDEN UNIV,DEPT PEDIAT,LEIDEN,NETHERLANDS

[3] NATL HEART & LUNG INST,LONDON SW3 6NP,ENGLAND

来源：

FREE RADICAL RESEARCH | 1995年 / 22卷 / 06期

关键词：

OXIDATIVE STRESS; CHELATABLE IRON; CERULOPLASMIN; ASCORBIC ACID; FERROUS IONS; FREE RADICALS; CORD BLOOD; NEONATES;

D O I：

10.3109/10715769509150327

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Redox active iron chelatable to bleomycin is often present in the plasma of cord blood samples taken from preterm and term babies. The low caeruloplasmin and high ascorbate levels in plasma at birth may allow this iron to exist in the reduced ferrous stare. In support of this postulate thirteen cord blood samples showing the presence of low molecular mass iron were able to degrade DNA in the presence of bleomycin and plasma.

引用

页码：555 / 559

页数：5

共 24 条

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