THE HUMAN-C/EBP-DELTA (CRP3/CELF) GENE - STRUCTURE AND CHROMOSOMAL LOCALIZATION

被引：34
作者：
CLEUTJENS, CBJM
VANEEKELEN, CCEM
VANDEKKEN, H
SMIT, EME
HAGEMEIJER, A
WAGNER, MJ
WELLS, DE
TRAPMAN, J
机构：
[1] ERASMUS UNIV ROTTERDAM,DEPT CELL BIOL & GENET,3000 DR ROTTERDAM,NETHERLANDS
[2] UNIV HOUSTON,DEPT BIOL,HOUSTON,TX 77204
[3] UNIV HOUSTON,INST MOLEC BIOL,HOUSTON,TX 77204
来源：
GENOMICS | 1993年 / 16卷 / 02期
关键词：
D O I：
10.1006/geno.1993.1220
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In an attempt to identify C/EBP-like transcription factors expressed in the prostate, a cDNA homologous to the mouse C/EBPδ (CRP3) and the rat CELF gene was isolated. A genomic clone containing the entire C/EBPδ gene was isolated using a cDNA fragment as a probe. The gene was characterized by restriction mapping and sequence analysis. By fluorescence in situ hybridization, using the biotinylated genomic clone as a probe, the C/EBPδ gene was assigned to the pericentromeric region of human chromosome 8, most probably to 8q11. This chromosomal localization was confirmed by analysis of a panel of human x hamster somatic cell hybrid DNA samples with a C/EBPδ-specific STS. As a result, the C/EBPδ gene could be positioned between the PLAT and the MOS loci. © 1993 Academic Press. All rights reserved.
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页码：520 / 523
页数：4
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