SERUM GASTRIN VALUES IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS

被引：3
作者：
SVENDSEN, LB
BISGARD, ML
GUSTAFSEN, J
BULOW, S
STADIL, F
机构：
[1] HVIDOVRE UNIV HOSP,DEPT SURG GASTROENTEROL,COPENHAGEN,DENMARK
[2] UNIV COPENHAGEN,INST HUMAN GENET,COPENHAGEN,DENMARK
来源：
DISEASES OF THE COLON & RECTUM | 1994年 / 37卷 / 01期
关键词：
FAMILIAL ADENOMATOUS POLYPOSIS; GASTRIN; COLORECTAL CANCER;
D O I：
10.1007/BF02047209
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
PURPOSE: An evaluation of the importance of gastrin in the colorectal carcinogenesis in patients with familial adenomatous polyposis was conducted. METHODS: Blood samples from 168 family members of 26 families were investigated for circulating gastrin. Blood was drawn from 65 affected patients, 66 clinically unaffected first-degree relatives, and 37 spouses. RESULTS: We did not find any difference in distribution of serum gastrin among these groups. CONCLUSION: Our results seem to exclude gastrin from being relevant in early carcinogenesis in patients with familial adenomatous polyposis.
引用
收藏
页码：22 / 25
页数：4
相关论文
共 38 条
[31]   GROWTH-FACTORS AND INTESTINAL NEOPLASMS [J].
TOWNSEND, CM ;
BEAUCHAMP, RD ;
SINGH, P ;
THOMPSON, JC .
AMERICAN JOURNAL OF SURGERY, 1988, 155 (03) :526-535
[32]  
UPP JR, 1989, CANCER RES, V49, P488
[33]   POLYAMINE LEVELS AND GASTRIN RECEPTORS IN COLON CANCERS [J].
UPP, JR ;
SAYDJARI, R ;
TOWNSEND, CM ;
SINGH, P ;
BARRANCO, SC ;
THOMPSON, JC .
ANNALS OF SURGERY, 1988, 207 (06) :662-669
[34]   ALLELOTYPE OF COLORECTAL CARCINOMAS [J].
VOGELSTEIN, B ;
FEARON, ER ;
KERN, SE ;
HAMILTON, SR ;
PREISINGER, AC ;
NAKAMURA, Y ;
WHITE, R .
SCIENCE, 1989, 244 (4901) :207-211
[35]   GENETIC ALTERATIONS DURING COLORECTAL-TUMOR DEVELOPMENT [J].
VOGELSTEIN, B ;
FEARON, ER ;
HAMILTON, SR ;
KERN, SE ;
PREISINGER, AC ;
LEPPERT, M ;
NAKAMURA, Y ;
WHITE, R ;
SMITS, AMM ;
BOS, JL .
NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (09) :525-532
[36]   GASTRIN - GROWTH ENHANCING EFFECTS ON HUMAN GASTRIC AND COLONIC TUMOR-CELLS [J].
WATSON, S ;
DURRANT, L ;
MORRIS, D .
BRITISH JOURNAL OF CANCER, 1989, 59 (04) :554-558
[37]  
WINSETT OE, 1986, SURGERY, V99, P302
[38]   POSTPRANDIAL HYPERGASTRINEMIA IN PATIENTS WITH COLORECTAL-CANCER [J].
WONG, K ;
BEARDSHALL, K ;
WATERS, CM ;
CALAM, J ;
POSTON, GJ .
GUT, 1991, 32 (11) :1352-1354
1234