INTRAVITREAL-U75412E - A NEW FREE-RADICAL SCAVENGER

被引：0
作者：
FISCELLA, R
GAGLIANO, DA
PEACHEY, NS
FEIST, R
DUNN, R
LAM, TT
机构：
[1] LETTERMAN ARMY MED CTR,DEPT OPHTHALMOL,SAN FRANCISCO,CA 94129
[2] LOYOLA UNIV,MED CTR,DEPT NEUROL,MAYWOOD,IL 60153
[3] NORTHWESTERN UNIV,DEPT BIOMED ENGN,EVANSTON,IL 60201
来源：
OPHTHALMIC SURGERY AND LASERS | 1991年 / 22卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Free-radical-mediated tissue damage is thought to be involved in a multitude of ophthalmic pathologies. Therefore, drugs that scavenge free radicals may find wide clinical application. A new chemical class of antiinflammatory agents, the 21-aminosteroids, has been developed as free radical scavengers. These agents are thought to inhibit lipid peroxidation and prevent the release of free arachidonic acid from injured cell membranes. In the present study, we investigated the intraocular toxicity of one of the 21-aminosteroids, U75412E. Intravitreal doses of up to 0.1 mg of U75412E were nontoxic to rabbit ocular tissues.
引用
收藏
页码：740 / 744
页数：5
相关论文
共 40 条
  • [1] AHLL E, 1988, EUR J PHARMACOL, V147, P299
  • [2] HYDROGEN-PEROXIDE LOCALIZATION IN OCULAR TISSUE - AN ELECTRON-MICROSCOPIC CYTOCHEMICAL STUDY
    ATALLA, LR
    SEVANIAN, A
    RAO, NA
    [J]. CURRENT EYE RESEARCH, 1988, 7 (09) : 931 - 936
  • [3] BISWAS J, 1989, INVEST OPHTHALMOL S, V30, P290
  • [4] BRAUGHLER J, 1989, DRUGS FUTURE, V2, P143
  • [5] NOVEL MEMBRANE LOCALIZED IRON CHELATORS AS INHIBITORS OF IRON-DEPENDENT LIPID-PEROXIDATION
    BRAUGHLER, JM
    BURTON, PS
    CHASE, RL
    PREGENZER, JF
    JACOBSEN, EJ
    VANDOORNIK, FJ
    TUSTIN, JM
    AYER, DE
    BUNDY, GL
    [J]. BIOCHEMICAL PHARMACOLOGY, 1988, 37 (20) : 3853 - 3860
  • [6] BRAUGHLER JM, 1987, J BIOL CHEM, V262, P10438
  • [7] BRAUGHLER JM, 1988, J PHARMACOL EXP THER, V244, P423
  • [8] ROLE OF FREE-RADICAL SCAVENGER IN PROTECTION OF SPINAL-CORD DURING ISCHEMIA
    COLES, JC
    AHMED, SN
    METHA, HU
    KAUFMANN, JCE
    [J]. ANNALS OF THORACIC SURGERY, 1986, 41 (05) : 551 - 556
  • [9] FLEISHER L, 1989, INVEST OPHTHALMOL S, V30, P287
  • [10] GRONAUER P, 1982, DOC OPHTHALMOL P SER, V31, P89
1234