STRUCTURE OF THE HUMAN INTERFERON-ALPHA RECEPTOR

被引：34
作者：
COLAMONICI, OR [1 ]
PFEFFER, LM [1 ]
机构：
[1] UNIV TENNESSEE CTR HLTH SCI,MED CTR,DEPT PATHOL,MEMPHIS,TN 38163
来源：
PHARMACOLOGY & THERAPEUTICS | 1991年 / 52卷 / 02期
关键词：
D O I：
10.1016/0163-7258(91)90010-J
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The structure of the IFN-alpha-receptor has been studied by methods such as affinity crosslinking and gel chromatography over the last 8 years. The recent development of monoclonal antibodies against the receptor, and the cloning of an IFN-alpha-receptor cDNA has provided new important tools to understand the IFN-alpha-receptor structure. Thus, it has become obvious that the IFN-alpha-receptor has a more complex structure than first anticipated, probably involving more than one subunit. This review analyzes the present knowledge about the structure of the IFN-alpha-receptor, a well as many unresolved issues concerning this topic.
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页码：227 / 233
页数：7
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