CHANGES IN EXTRACELLULAR AMINO-ACID NEUROTRANSMITTERS PRODUCED BY FOCAL CEREBRAL-ISCHEMIA

被引：155

作者：

GRAHAM, SH

SHIRAISHI, K

PANTER, SS

SIMON, RP

FADEN, AI

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT NEUROL,SAN FRANCISCO,CA 94143

[2] SAN FRANCISCO GEN HOSP,DEPT NEUROL,SAN FRANCISCO,CA 94110

来源：

NEUROSCIENCE LETTERS | 1990年 / 110卷 / 1-2期

关键词：

Aspartate; Cerebral ischemia; GABA; Glutamate; Microdialysis;

D O I：

10.1016/0304-3940(90)90799-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Excitatory amino acids (EAAs) have been implicated in the pathophysiology of cellular injury after brain ischemia. Changes in extracellular levels of amino acids in rat cerebral cortex after permanent proximal middle cerebral artery (MCA) occlusion were examined using microdialysis. Significant increases were found in dialysate concentrations of glutamate, aspartate and γ-aminobutyric acid (GABA) from the ischemic cortex during the first 90 min after MCA occlusion compared to pre-ischemic concentrations and contralateral hemispheric controls. Total tissue levels of these amino acids in the infarcted hemisphere 90 min after onset of ischemia were not different from the contralateral hemisphere. These results are consistent with the hypothesis that the release of EAAs may contribute to tissue damage in focal cerebral ischemia. © 1990.

引用

页码：124 / 130

页数：7

共 26 条

[21]

ROTHMAN S, 1984, J NEUROSCI, V4, P1884

[22] GLUTAMATE AND THE PATHOPHYSIOLOGY OF HYPOXIC ISCHEMIC BRAIN-DAMAGE [J].