COVALENT BINDING OF [C-14]-LABELED METHOXYCHLOR METABOLITE(S) TO RAT-LIVER MICROSOMAL COMPONENTS

被引：34
作者：
BULGER, WH [1 ]
TEMPLE, JE [1 ]
KUPFER, D [1 ]
机构：
[1] WORCESTER FDN EXPTL BIOL,222 MAPLE AVE,SHREWSBURY,MA 01545
来源：
TOXICOLOGY AND APPLIED PHARMACOLOGY | 1983年 / 68卷 / 03期
关键词：
D O I：
10.1016/0041-008X(83)90280-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：367 / 374
页数：8
相关论文
共 30 条
[1]   ENHANCEMENT AND INHIBITION OF DRUG METABOLISM [J].
ANDERS, MW .
ANNUAL REVIEW OF PHARMACOLOGY, 1971, 11 :37-&
[2]  
BAKER MT, 1982, FED PROC, V41, P1054
[3]   POSSIBLE MECHANISM OF LIVER NECROSIS CAUSED BY AROMATIC ORGANIC COMPOUNDS [J].
BRODIE, BB ;
REID, WD ;
CHO, AK ;
SIPES, G ;
KRISHNA, G ;
GILLETTE, JR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (01) :160-&
[4]   STUDIES ON INVIVO AND INVITRO ESTROGENIC ACTIVITIES OF METHOXYCHLOR AND ITS METABOLITES ROLE OF HEPATIC MONO-OXYGENASE IN METHOXYCHLOR ACTIVATION [J].
BULGER, WH ;
MUCCITELLI, RM ;
KUPFER, D .
BIOCHEMICAL PHARMACOLOGY, 1978, 27 (20) :2417-2423
[5]   HYDROXYLATION OF TRANS-DELTA-1-TETRAHYDROCANNABINOL BY HEPATIC MICROSOMAL OXYGENASE [J].
BURSTEIN, S ;
KUPFER, D .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1971, 191 (DEC31) :61-&
[6]   PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .1. CORRELATION OF CHANGES IN COVALENT BINDING OF REACTIVITY METABOLITES WITH CHANGES IN INCIDENCE AND SEVERITY OF TOXICITY [J].
GILLETTE, JR .
BIOCHEMICAL PHARMACOLOGY, 1974, 23 (20) :2785-2794
[7]   BIOCHEMICAL MECHANISMS OF DRUG TOXICITY [J].
GILLETTE, JR ;
MITCHELL, JR ;
BRODIE, BB .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1974, 14 :271-288
[8]   PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .2. ALTERATIONS IN KINETICS OF COVALENT BINDING [J].
GILLETTE, JR .
BIOCHEMICAL PHARMACOLOGY, 1974, 23 (21) :2927-2938
[9]   REACTIONS OF OH, CH2OH, BR2-, AND (CNS)2-FREE RADICALS WITH CYSTEINE AT PH5.3 [J].
GOYAL, GC ;
ARMSTRONG, DA .
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1975, 53 (10) :1475-1479
[10]  
IVANETICH KM, 1982, RES COMMUN CHEM PATH, V35, P111
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