Black Cohosh and Liver Toxicity: Is There a Relationship?

被引:10
作者
Adnan, Mohammed Muqeet [1 ]
Khan, Muhammad [1 ]
Hashmi, Syed [1 ]
Hamza, Muhammad [2 ]
AbdulMujeeb, Sufyan [3 ]
Amer, Syed [4 ]
机构
[1] Univ Oklahoma, Hlth Sci Ctr, Dept Internal Med, Oklahoma City, OK 73112 USA
[2] Dow Med Coll, Karachi 74200, Pakistan
[3] Univ Illinois, Chicago, IL 60680 USA
[4] Mayo Clin Arizona, Phoenix, AZ 85054 USA
关键词
D O I
10.1155/2014/860614
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Herbal supplements are commonly used by patients for various problems. It is a well-known fact that most patients do not tell their physicians about the use of herbal supplements unless they are specifically asked. As a result, sometimes important information regarding drug side effects is missed in history taking. During our literature search, we found several retrospective studies and other meta-analyses that claim a lacking or weak link between black cohosh use and hepatotoxicity. We present a case of a 44-year-old female who developed subacute liver injury demonstrated on a CT scan and liver biopsy within amonth of using the drug to resolve her hot flashes and discuss a possible temporal and causal association between black cohosh use and liver disease. Since the patient was not taking any other drugs, we concluded that the acute liver injury was caused by the use of black cohosh. We agree with the United States Pharmacopeia recommendations that a cautionary warning about hepatotoxicity should be labeled on the drug package.
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页数:3
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