BACILLOPEPTINS, NEW CYCLIC LIPOPEPTIDE ANTIBIOTICS FROM BACILLUS-SUBTILIS FR-2

被引:64
作者
KAJIMURA, Y
SUGIYAMA, M
KANEDA, M
机构
[1] HIROSHIMA UNIV,SCH MED,INST PHARMACEUT SCI,MINAMI KU,HIROSHIMA 734,JAPAN
[2] WAKUNAGA PHARMACEUT CO LTD,CENT RES LABS,HIROSHIMA 73911,JAPAN
关键词
D O I
10.7164/antibiotics.48.1095
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Bacillopeptins, new iturin-group antifungal antibiotics, were isolated from the culture broth of Bacillus subtilis FR-2 obtained from the rhizosphere of garlic suffering from the basal rot caused by Fusarium oxysporum. Their structures were elucidated to be cyclic lipopeptides similar to bacillomycin L by NMR and mass spectral studies coupled with amino acid analysis. The absolute configuration of each amino acid residue was determined by chiral HPLC.
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页码:1095 / 1103
页数:9
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