GENE-DOSAGE MAPPING OF 30 DNA MARKERS ON CHROMOSOME-21

被引：12
作者：
DELABAR, JM
CHETTOUH, Z
RAHMANI, Z
THEOPHILE, D
BLOUIN, JL
BONO, R
KRAUS, J
BARTON, J
PATTERSON, D
SINET, PM
机构：
[1] INST PASTEUR, INSERM, U276, F-75724 PARIS 15, FRANCE
[2] UNIV COLORADO, HLTH SCI CTR, DENVER, CO 80262 USA
[3] ELEANOR ROOSEVELT INST, DENVER, CO 80206 USA
来源：
GENOMICS | 1992年 / 13卷 / 03期
关键词：
D O I：
10.1016/0888-7543(92)90177-T
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Using a slot-blot method for the dosage of single-copy sequences, the copy numbers of 30 chromosome 21 markers were assessed in the blood DNA of 11 patients with partial trisomy or monosomy 21 and in the DNA of a patient-derived human-hamster hybrid cell line carrying a microduplication of chromosome 21. The physical order of these markers on chromosome 21 was thereby determined. © 1992.
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页码：887 / 889
页数：3
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