TRANSIENT EXPRESSION OF NEUROTENSIN MESSENGER-RNA IN THE MITRAL CELLS OF RAT OLFACTORY-BULB DURING DEVELOPMENT

被引：10
|
作者：
KIYAMA, H
SATO, M
EMSON, PC
TOHYAMA, M
机构：
[1] OSAKA UNIV,SCH MED,BIOMED RES CTR,DEPT NEUROANAT,SUITA,OSAKA 565,JAPAN
[2] INST ANIM PHYSIOL & GENET RES,MRC GRP,CAMBRIDGE RES STN,CAMBRIDGE,ENGLAND
来源：
NEUROSCIENCE LETTERS | 1991年 / 128卷 / 01期
基金：
日本学术振兴会;
关键词：
PREPRONEUROTENSIN; NEUROMEDIN-N; ONTOGENY; NONRADIOACTIVE INSITU HYBRIDIZATION;
D O I：
10.1016/0304-3940(91)90765-L
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The transient expression of neurotensin mRNA in the mitral cells of the rat olfactory bulb was demonstrated during the perinatal period using non-radioactive in situ hybridization in which an alkaline phosphatase labelled oligodeoxynucleotide probe was used. The relative cellular content of neurotensin mRNA signal was measured by use of a microdensitometer. Neurotensin mRNA positive cells were observed in the primordium of mitral cells on embryonic day 14 and their mRNA content increased gradually up to the day of birth. During the first postnatal week, the strength of their neurotensin mRNA signal decreased dramatically, and continued to decrease until in the adult olfactory bulb neurotensin mRNA was no longer detectable. This decrease of the neurotensin mRNA content coincided with a parallel decrease of neurotensin immunoreactivity observed in the lateral olfactory tract.
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页码：85 / 89
页数：5
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