IDIOTYPIC SELECTION OF AN ANTIBODY MUTANT WITH CHANGED HAPTEN BINDING-SPECIFICITY, RESULTING FROM A POINT MUTATION IN POSITION-50 OF THE HEAVY-CHAIN

被引：53

作者：

BRUGGEMANN, M ^{[1
]}

MULLER, HJ ^{[1
]}

BURGER, C ^{[1
]}

RAJEWSKY, K ^{[1
]}

机构：

[1] UNIV COLOGNE,INST GENET,D-5000 COLOGNE 41,FED REP GER

来源：

EMBO JOURNAL | 1986年 / 5卷 / 07期

关键词：

D O I：

10.1002/j.1460-2075.1986.tb04397.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1561 / 1566

页数：6

共 44 条

[21] RECOMBINATION BETWEEN ANTIBODY HEAVY-CHAIN VARIABLE-REGION GENES - EVIDENCE FOR GENE CONVERSION [J].

KRAWINKEL, U ;

ZOEBELEIN, G ;

BRUGGEMANN, M ;

RADBRUCH, A ;

RAJEWSKY, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (16) :4997-5001

[22] EK2 DERIVATIVES OF BACTERIOPHAGE-LAMBDA USEFUL IN CLONING OF DNA FROM HIGHER ORGANISMS - LAMBDAGTWES SYSTEM [J].

LEDER, P ;

TIEMEIER, D ;

ENQUIST, L .

SCIENCE, 1977, 196 (4286) :175-177

[23] GENERATION OF ANTIBODY DIVERSITY IN THE IMMUNE-RESPONSE OF BALB-C MICE TO INFLUENZA-VIRUS HEMAGGLUTININ [J].

MCKEAN, D ;

HUPPI, K ;

BELL, M ;

STAUDT, L ;

GERHARD, W ;

WEIGERT, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (10) :3180-3184

[24]

MULLER CE, 1983, J IMMUNOL, V131, P877

[25] EXPRESSION AND REGULATION OF IMMUNOGLOBULIN HEAVY-CHAIN GENE TRANSFECTED INTO LYMPHOID-CELLS [J].

NEUBERGER, MS .

EMBO JOURNAL, 1983, 2 (08) :1373-1378

[26] SWITCH FROM HAPTEN-SPECIFIC IMMUNOGLOBULIN-M TO IMMUNOGLOBULIN-D SECRETION IN A HYBRID MOUSE-CELL LINE [J].

NEUBERGER, MS ;

RAJEWSKY, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (02) :1138-1142

[27] ANTIGEN-BINDING SPECIFICITIES OF ANTIBODIES ARE PRIMARILY DETERMINED BY 7 RESIDUES OF VH [J].

OHNO, S ;

MORI, N ;

MATSUNAGA, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (09) :2945-2949

[28] IMMUNOGLOBULIN GENE-EXPRESSION IN TRANSFORMED LYMPHOID-CELLS [J].

OI, VT ;

MORRISON, SL ;

HERZENBERG, LA ;

BERG, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (03) :825-829

[29] ENHANCER-DEPENDENT EXPRESSION OF HUMAN KAPPA-IMMUNOGLOBULIN GENES INTRODUCED INTO MOUSE PRE-B LYMPHOCYTES BY ELECTROPORATION [J].

POTTER, H ;

WEIR, L ;

LEDER, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (22) :7161-7165

[30] DRASTIC CHANGE IN IDIOTYPIC BUT NOT ANTIGEN-BINDING SPECIFICITY OF AN ANTIBODY BY A SINGLE AMINO-ACID SUBSTITUTION [J].

RADBRUCH, A ;

ZAISS, S ;

KAPPEN, C ;

BRUGGEMANN, M ;

BEYREUTHER, K ;

RAJEWSKY, K .

NATURE, 1985, 315 (6019) :506-508

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