SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES ON Co (II), Ni (II), Cu (II) AND Zn (II) COMPLEXES OF N, O, DONAR HETEROCYCLIC SCHIFF BASES

The Schiff base ligands L-1 4-allyl-2-{[(5'-methyl-3'-isoxazolyl) imino] methyl} phenol [AMIIMP] and L-2 N-[5'-methyl-3'-isoxazolyl]-[(E) Pyridine)] methylidine] amine[MIPMA] have been synthesized by the condensation of 4-allyl 2-hydroxyl 1-benzaldehyde and Pyridine 3carboxaldehyde with 3-amino 5-methy isoxazole. The metal chelates of L-1 and L-2 with Cobalt (II), Nickel (II), Copper (II) and Zn (II) metal ions have been synthesised and characterized on the basis of elemental analysis, IR, 1 H-NMR, Mass, Electronic spectra and magnetic moment studies. From these studies it is found that ligands act as bivalent chelating agents coordinating through oxygen and nitrogen donor atoms in the case of AMIIMP, and pyridine nitrogen and imino nitrogen donar atoms of in the case of MIPMA. The chelates of Co (II), Ni (II) and Zn (II) appear to be octahedral geometry and Cu (II) appears to be tetragonal geometry. Antimicrobial activity of the ligands and their metal complexes against bacteria (Bacillus, Pseudomonas) and fungus (R. Solani, A. Niger) has been carried out. It is found that the metal complexes have higher activities than those of free ligands.