INHIBITION OF HERPES-SIMPLEX VIRUS TYPE-1 MULTIPLICATION BY MELIACINE, A PEPTIDE OF PLANT-ORIGIN

被引：22

作者：

VILLAMIL, SM

ALCHE, LE

COTO, CE

机构：

[1] Lab. of Virology, Faculty of Science, University of Buenos Aires, Ciudad Univ., Pabellon II, 4to.

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1995年 / 6卷 / 04期

关键词：

ANTIVIRAL ACTIVITY; HSV-1; MELIACINE; PROTEIN SYNTHESIS INHIBITION;

D O I：

10.1177/095632029500600406

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Meliacine, a peptide isolated from leaves of Melia azedarach L., exhibited potent activity against herpes simplex type 1 (HSV-1). The in vitro selective indices for pre- and post-treatment were 937.5 and 2500, respectively. Analysis of early events following infection showed that meliacine did not affect viral adsorption and penetration. Meliacine strongly inhibited specific infected-cell polypeptides (ICPs) produced late,in infection. The antiviral activity, Which is attributed mainly to this selective effect, was also demonstrated in an immunofluorescence assay.

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页码：239 / 244

页数：6

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