PINEAL SEROTONIN N-ACETYLTRANSFERASE - EXPRESSION CLONING AND MOLECULAR ANALYSIS

被引：305
作者：
COON, SL
ROSEBOOM, PH
BALER, R
WELLER, JL
NAMBOODIRI, MAA
KOONIN, EV
KLEIN, DC
机构：
[1] NICHHD, DEV NEUROBIOL LAB, NEUROBIOL SECT, BETHESDA, MD 20892 USA
[2] GEORGETOWN UNIV, DEPT BIOL, WASHINGTON, DC 20057 USA
[3] NATL LIB MED, NATL CTR BIOTECHNOL INFORMAT, BETHESDA, MD 20894 USA
来源：
SCIENCE | 1995年 / 270卷 / 5242期
关键词：
D O I：
10.1126/science.270.5242.1681
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Pineal serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, or AA-NAT) generates the large circadian rhythm in melatonin, the hormone that coordinates daily and seasonal physiology in some mammals. Complementary DNA encoding ovine AA-NAT was cloned. The abundance of AA-NAT messenger RNA (mRNA) during the day was high in the ovine pineal gland and somewhat lower in retina. AA-NAT mRNA was found unexpectedly in the pituitary gland and in some brain regions. The night-to-day ratio of ovine pineal AA-NAT mRNA is less than 2. In contrast, the ratio exceeds 150 in rats. AA-NAT represents a family within a large superfamily of acetyltransferases.
引用
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页码：1681 / 1683
页数：3
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