NOVEL GENETICALLY-ENGINEERED TETRACENOMYCINS

被引：40
作者：
DECKER, H
HAAG, S
UDVARNOKI, G
ROHR, J
机构：
[1] UNIV GOTTINGEN,INST ORGAN CHEM,D-37077 GOTTINGEN,GERMANY
[2] UNIV TUBINGEN,INST BIOL 2,D-72076 TUBINGEN,GERMANY
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 10期
关键词：
BIOSYNTHESIS; GENE TECHNOLOGY; POLYKETIDES; TETRACENOMYCINS;
D O I：
10.1002/anie.199511071
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Genetically engineered hybrid strains, in which the genes of the urdamycin‐producer Streptomyce fradiae are combined with some of the biosynthetic genes of the elloramycin‐producer Streptomyces olivaceus or the genes of the tetracenomycin‐producer Streptomyces glaucescens, assemble novel hybrid antibiotics of the tetracenomycin type. The results prove that this combinatorial biosynthesis method may be a useful alternative for the production of new natural products which can then be screened. Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany
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页码：1107 / 1110
页数：4
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