INVOLVEMENT OF FIBRONECTIN AND INTERACTING SERUM COMPONENTS IN THE REGULATION OF ACTIVITY OF HUMAN NATURAL-KILLER-CELLS

被引：0
|
作者：
CHEKNEV, SB
KUYAVSKAYA, DV
TARKHANOVA, IA
BABAEVA, EE
BARTOVA, LM
KULBERG, AY
机构：
[1] Laboratory of Immunochemistry, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1994年 / 118卷 / 07期
关键词：
NATURAL KILLER CELLS; FIBRONECTIN; REGULATION;
D O I：
10.1007/BF02444373
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The cytotoxic activity of natural killer cells and the intensity of conjugate formation are studied in vitro in the natural cytotoxicity reaction against H-3-uridine-labeled human erythromyeloleukotic cells K-562 in the presence of fibronectin, gamma-globulin, and fibronectin/gamma-globulin combination. It is demonstrated that fibronectin does not change natural cytotoxicity, gamma-globulin increases the activity of human natural killer cells, and the fibronectin - gamma-globulin combination increases both the intensity of conjugate formation and the cytotoxic activity of natural killer cells.
引用
收藏
页码：737 / 742
页数：6
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