CORRELATION OF HEAT-SHOCK PROTEIN-70 EXPRESSION WITH ESTROGEN-RECEPTOR LEVELS IN INVASIVE HUMAN BREAST-CANCER

被引：0

作者：

TAKAHASHI, S

MIKAMI, T

WATANABE, Y

OKAZAKI, M

OKAZAKI, Y

OKAZAKI, A

SATO, T

ASAISHI, K

HIRATA, K

NARIMATSU, E

MORI, M

SATO, N

KIKUCHI, I

机构：

[1] SAPPORO MED UNIV,DEPT PATHOL,SAPPORO,HOKKAIDO,JAPAN

[2] SAPPORO MED UNIV,DEPT SURG,SAPPORO,HOKKAIDO,JAPAN

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 1994年 / 101卷 / 04期

关键词：

BREAST CANCER; C-ERBB-2; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; HEAT SHOCK PROTEIN 70; IMMUNOHISTOCHEMISTRY P53;

D O I：

暂无

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The authors studied the role of 70-Kd heat shock protein (HSP70) in the progression of breast cancer by examining the correlation between the expression of HSP70 and epidermal growth factor receptor, c-erbB-2, p53, and estrogen receptor in 124 cases of invasive primary human breast cancers. Positivity of an anti-HSP70 monoclonal antibody, C92, was closely associated with the elevation of estrogen receptor (P < .008), whereas it inversely correlated with the expression of p53 (P < .01). In addition, the expression of HSP70 correlated inversely with the expression of epidermal growth factor receptor, although the correlation was not statistically significant (P = .06). These results suggest that the expression of HSP70 plays a role in the progression of human breast cancer.

引用

页码：519 / 525

页数：7

共 44 条

[1] PURIFICATION OF AN ESTROGEN-REGULATED BREAST-CANCER PROTEIN BY MONOCLONAL-ANTIBODY AFFINITY-CHROMATOGRAPHY [J].