SYNTHESIS OF 1,5-DIDEOXY-3-O-(ALPHA-D-MANNOPYRANOSYL)-1,5-IMINO-D-MANNITOL AND 1,5-DIDEOXY-3-O-(ALPHA-D-GLUCOPYRANOSYL)-1,5-IMINO-D-MANNITOL - POWERFUL INHIBITORS OF ENDOMANNOSIDASE

被引：17
作者：
ARDRON, H
BUTTERS, TD
PLATT, FM
WORMALD, MR
DWEK, RA
FLEET, GWJ
JACOB, GS
机构：
[1] MONSANTO CO,ST LOUIS,MO 63167
[2] UNIV OXFORD,DEPT BIOCHEM,GLYCOBIOL INST,OXFORD OX1 3QU,ENGLAND
来源：
TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 09期
关键词：
D O I：
10.1016/S0957-4166(00)82250-8
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis and conformations of 3-O-methylDMJ, 3-O-(alpha-D-glucopyranosyl)-DMJ (Glcalpha1,3DMJ), and 3-O-(alpha-D-mannopyranosyl)-DMJ (Manalpha1,3DMJ) are described. Manalpha1,3DMJ and Glcalpha1,3DMJ are shown to be very powerful inhibitors of an endomannosidase. The potential use of these compounds in both probing the pathways of N-linked glycoprotein processing and in the chemotherapy of some viral diseases is discussed.
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页码：2011 / 2024
页数：14
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