CORTICAL SEROTONIN RECEPTOR SUBTYPES AFTER LESION OF ASCENDING CHOLINERGIC NEURONS IN RAT

被引：16

作者：

CROSS, AJ ^{[1
]}

DEAKIN, JFW ^{[1
]}

机构：

[1] UNIV MANCHESTER, DEPT PSYCHIAT, MANCHESTER M13 9PL, LANCS, ENGLAND

来源：

NEUROSCIENCE LETTERS | 1985年 / 60卷 / 03期

关键词：

D O I：

10.1016/0304-3940(85)90587-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin (5-HT) S1 and S2 receptors were studied in rat cortex after lesion of the ascending cholinergic systems by injection of ibotenic acid into the nucleus basalis. The lesions produced a large (56%) decrease in choline acetyltransferase activity with no change in markers of .gamma.-aminobutyric acid, dopamine and 5-HT containing neurones. Lesions of the ascending cholinergic neurones were accompanied by a loss of 5-HT S1 receptor binding sites with no change in S2 receptors. These results suggest that a proportion of S1 receptors may be associated with cholinergic terminals.

引用

页码：261 / 265

页数：5

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