Transcriptome sequencing of hematopoietic stem cells and chronic myelgenous leukemia stem cells

被引：4
|
作者：
Kim, Junil [1 ]
Kim, Seong-Jin [1 ,2 ]
Naka, Kazuhito [3 ,4 ]
机构：
[1] CHA Univ, CHA Canc Inst, CHA Bio Complex,335 Pangyo Ro, Songnam 463400, Kyunggi Do, South Korea
[2] CHA Univ, Dept Biomed Sci, CHA Bio Complex,335 Pangyo Ro, Songnam 463400, Kyunggi Do, South Korea
[3] Kanazawa Univ, Canc Res Inst, Exploratory Project Canc Stem Cells, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan
[4] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Stem Cell Biol, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan
来源：
GENOMICS DATA | 2016年 / 7卷
关键词：
Chronic myelogenous leukemia; CML stem cell; Dipeptide transporter; RNA sequencing; Slc15a2;
D O I：
10.1016/j.gdata.2015.11.017
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Dipeptide species are accumulated in the chronic myelogenous leukemia (CML) stem cells [1]. To investigate the molecular mechanisms of the accumulation of dipeptide species in CML stem cells, we performed transcriptome sequencing of long-term stem cells, short-term stem cells, progenitor cells from healthy control and CML-affected mice (GSE70031). The transcriptome data revealed that the expression of a dipeptide transporter (solute carrier family 15, member 2 (SLC15A2)) was elevated only in the CML stem cells. This result indicates that dipeptide species accumulates in CML stem cells through a dipeptide transporter SLC15A2. (c) 2015 The Authors. Published by Elsevier Inc.
引用
收藏
页码：57 / 59
页数：3
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