Transcriptome sequencing of hematopoietic stem cells and chronic myelgenous leukemia stem cells

被引：4

作者：

Kim, Junil ^{[1
]}

Kim, Seong-Jin ^{[1
,2
]}

Naka, Kazuhito ^{[3
,4
]}

机构：

[1] CHA Univ, CHA Canc Inst, CHA Bio Complex,335 Pangyo Ro, Songnam 463400, Kyunggi Do, South Korea

[2] CHA Univ, Dept Biomed Sci, CHA Bio Complex,335 Pangyo Ro, Songnam 463400, Kyunggi Do, South Korea

[3] Kanazawa Univ, Canc Res Inst, Exploratory Project Canc Stem Cells, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan

[4] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Stem Cell Biol, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan

来源：

GENOMICS DATA | 2016年 / 7卷

关键词：

Chronic myelogenous leukemia; CML stem cell; Dipeptide transporter; RNA sequencing; Slc15a2;

D O I：

10.1016/j.gdata.2015.11.017

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Dipeptide species are accumulated in the chronic myelogenous leukemia (CML) stem cells [1]. To investigate the molecular mechanisms of the accumulation of dipeptide species in CML stem cells, we performed transcriptome sequencing of long-term stem cells, short-term stem cells, progenitor cells from healthy control and CML-affected mice (GSE70031). The transcriptome data revealed that the expression of a dipeptide transporter (solute carrier family 15, member 2 (SLC15A2)) was elevated only in the CML stem cells. This result indicates that dipeptide species accumulates in CML stem cells through a dipeptide transporter SLC15A2. (c) 2015 The Authors. Published by Elsevier Inc.

引用

页码：57 / 59

页数：3