7-NITRO-INDAZOLE, A SELECTIVE INHIBITOR OF NEURONAL NITRIC-OXIDE SYNTHASE, REDUCES FORMALIN EVOKED C-FOS EXPRESSION IN DORSAL HORN NEURONS OF THE RAT SPINAL-CORD

被引：34

作者：

CHAPMAN, V ^{[1
]}

BURITOVA, J ^{[1
]}

HONORE, P ^{[1
]}

BESSON, JM ^{[1
]}

机构：

[1] EPHE,F-75014 PARIS,FRANCE

来源：

BRAIN RESEARCH | 1995年 / 697卷 / 1-2期

基金：

澳大利亚研究理事会;

关键词：

NITRIC OXIDE; NOCICEPTION; SPINAL CORD;

D O I：

10.1016/0006-8993(95)00973-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of intravenous 7-nitro-indazole (7NI), a selective inhibitor of neuronal nitric oxide synthase, on intraplantar formalin evoked spinal expression of c-Fos was studied. The spinal expression of c-Fos in the superficial laminae of the dorsal horn was not significantly altered by 7NI. In contrast formalin evoked c-Fos expression in the deep laminae was reduced by 15 mg/kg of 7NI (42 +/- 8% reduction of control P < 0.05). Formalin evoked inflammation was not influenced by 7NI. Our results implicate a functional relationship between c-Fos expression and nitric oxide, at the spinal level, under inflammatory conditions.

引用

收藏

页码：258 / 261

页数：4

相关论文

共 19 条

[1] C-FOS EXPRESSION IN RAT LUMBAR SPINAL-CORD DURING THE DEVELOPMENT OF ADJUVANT-INDUCED ARTHRITIS [J].

ABBADIE, C ;

BESSON, JM .

NEUROSCIENCE, 1992, 48 (04) :985-993

[2]

Abbadie C, 1994, NATO ADV SCI INST SE, V79, P449

[3] THE INFLUENCE OF THE CYCLOSPORINE VEHICLE, CREMOPHOR EL, ON RENAL MICROVASCULAR BLOOD-FLOW IN THE RAT [J].

ABRAHAM, JS ;

BENTLEY, FR ;

GARRISON, RN ;

CRYER, HM .

TRANSPLANTATION, 1991, 52 (01) :101-105

[4] INHIBITION OF RAT CEREBELLAR NITRIC-OXIDE SYNTHASE BY 7-NITRO INDAZOLE AND RELATED SUBSTITUTED INDAZOLES [J].

BABBEDGE, RC ;

BLANDWARD, PA ;

HART, SL ;

MOORE, PK .

BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 (01) :225-228

[5] REGIONAL AND CARDIAC HEMODYNAMIC-EFFECTS OF NG-NITRO-L-ARGININE METHYL-ESTER IN CONSCIOUS, LONG EVANS RATS [J].

GARDINER, SM ;

COMPTON, AM ;

KEMP, PA ;

BENNETT, T .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 101 (03) :625-631

[6] ELECTROPHYSIOLOGICAL EVIDENCE FOR A ROLE OF NITRIC-OXIDE IN PROLONGED CHEMICAL NOCICEPTION IN THE RAT [J].

HALEY, JE ;

DICKENSON, AH ;

SCHACHTER, M .

NEUROPHARMACOLOGY, 1992, 31 (03) :251-258

[7] EXPRESSION OF NITRIC-OXIDE SYNTHASE AND COLOCALIZATION WITH JUN, FOS AND KROX TRANSCRIPTION FACTORS IN SPINAL-CORD NEURONS FOLLOWING NOXIOUS-STIMULATION OF THE RAT HINDPAW [J].

HERDEGEN, T ;

RUDIGER, S ;

MAYER, B ;

BRAVO, R ;

ZIMMERMANN, M .

MOLECULAR BRAIN RESEARCH, 1994, 22 (1-4) :245-258

[8] REDUCTION OF CARRAGEENAN EDEMA AND THE ASSOCIATED C-FOS EXPRESSION IN THE RAT LUMBAR SPINAL-CORD BY NITRIC-OXIDE SYNTHASE INHIBITOR [J].

HONORE, P ;

CHAPMAN, V ;

BURITOVA, J ;

BESSON, JM .

BRITISH JOURNAL OF PHARMACOLOGY, 1995, 114 (01) :77-84

[9] NITRIC-OXIDE MEDIATES FOS EXPRESSION IN THE SPINAL-CORD INDUCED BY MECHANICAL NOXIOUS-STIMULATION [J].

LEE, JH ;

WILCOX, GL ;

BEITZ, AJ .

NEUROREPORT, 1992, 3 (10) :841-844

[10] NITRIC-OXIDE SYNTHASE IS FOUND IN SOME SPINOTHALAMIC NEURONS AND IN NEURONAL PROCESSES THAT APPOSE SPINAL NEURONS THAT EXPRESS FOS INDUCED BY NOXIOUS-STIMULATION [J].

LEE, JH ;

PRICE, RH ;

WILLIAMS, FG ;

MAYER, B ;

BEITZ, AJ .

BRAIN RESEARCH, 1993, 608 (02) :324-333