DETERMINATION OF CIMETIDINE IN HUMAN PLASMA BY FREE CAPILLARY ZONE ELECTROPHORESIS

被引:0
作者
LUKSA, J [1 ]
JOSIC, D [1 ]
机构
[1] PHARMAZEUT PROD MBH,OCTAPHARMA,A-1100 VIENNA,AUSTRIA
来源
JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 667卷 / 02期
关键词
D O I
暂无
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The separation of cimetidine from the metabolites cimetidine amide and cimetidine sulfoxide, endogenous creatinine and the internal standard ranitidine was achieved by capillary electrophoresis in less than 5 min. All compounds were well separated from cimetidine, including possible plasma ingredients, as the UV spectra of cimetidine standard and cimetidine from the plasma extract match. Plasma levels of cimetidine were determined in the range 250-3000 ng/ml in plasma and higher concentrations were determined by dilution of the sample with blank plasma.
引用
收藏
页码:321 / 327
页数:7
相关论文
共 50 条
[31]   Determination of ethyl sulfate in human serum and urine by capillary zone electrophoresis [J].
Jung, Balthasar ;
Caslavska, Jitka ;
Thormann, Wolfgang .
JOURNAL OF CHROMATOGRAPHY A, 2008, 1206 (01) :26-32
[32]   Direct electrochemical determination of pyruvate in human sweat by capillary zone electrophoresis [J].
Jin, ML ;
Dong, Q ;
Dong, R ;
Jin, WR .
ELECTROPHORESIS, 2001, 22 (13) :2793-2796
[33]   Determination of ethyl glucuronide in human serum by capillary zone electrophoresis and an immunoassay [J].
Jung, Balthasar ;
Caslavska, Jitka ;
Thormann, Wolfgang .
JOURNAL OF SEPARATION SCIENCE, 2009, 32 (20) :3497-3506
[34]   Determination of daunorubicin in human urine by capillary zone electrophoresis with amperometric detection [J].
Hu, Q ;
Zhang, L ;
Zhou, TS ;
Fang, YZ .
ANALYTICA CHIMICA ACTA, 2000, 416 (01) :15-19
[35]   Determination of idarubicin in human urine by capillary zone electrophoresis with amperometric detection [J].
Q. Hu ;
T. Zhou ;
L. Zhang ;
H. Li ;
Y. Fang .
Fresenius' Journal of Analytical Chemistry, 2000, 368 :844-847
[36]   Determination of idarubicin in human urine by capillary zone electrophoresis with amperometric detection [J].
Hu, Q ;
Zhou, TS ;
Zhang, L ;
Li, H ;
Fang, YZ .
FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY, 2000, 368 (08) :844-847
[37]   DIRECT DETERMINATION OF EPHEDRINE AND NOREPHEDRINE IN HUMAN URINE BY CAPILLARY ZONE ELECTROPHORESIS [J].
CHICHARRO, M ;
ZAPARDIEL, A ;
BERMEJO, E ;
PEREZ, JA ;
HERNANDEZ, L .
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1993, 622 (01) :103-108
[38]   Determination of homocysteine and other thiols in human plasma by capillary electrophoresis [J].
Kang, SH ;
Kim, JW ;
Chung, DS .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1997, 15 (9-10) :1435-1441
[39]   Determination of Free Calcium in Human Plasma by Capillary Electrophoresis-Inductively Coupled Plasma Atomic Emission Spectrometry [J].
Zhu Ping-Chuan ;
Xu Xiang-Shu ;
Xiao Yan ;
Yang Kun-Guo ;
Deng Bi-Yang .
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2008, 36 (11) :1555-1558
[40]   Determination of trimebutine maleate in rat plasma and tissues by using capillary zone electrophoresis [J].
Li, FM ;
Yu, LN .
BIOMEDICAL CHROMATOGRAPHY, 2001, 15 (04) :248-251