ENHANCED EXPRESSION OF RAT OBESE (OB) GENE IN ADIPOSE TISSUES OF VENTROMEDIAL HYPOTHALAMUS (VMH)-LESIONED RATS

被引：127
作者：
FUNAHASHI, T
SHIMOMURA, I
HIRAOKA, H
ARAI, T
TAKAHASHI, M
NAKAMURA, T
NOZAKI, S
YAMASHITA, S
TAKEMURA, K
TOKUNAGA, K
MATSUZAWA, Y
机构：
[1] Second Department of Internal Medicine, Osaka University, Medical School, Suita, Osaka, 565
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 211卷 / 02期
关键词：
D O I：
10.1006/bbrc.1995.1837
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A responsible gene of genetically obese (ob/ob) mouse has recently been isolated. Genetic disruption of ob gene causes massive obesity. To elucidate the pathophysiological regulation of ob gene, we examined the gene expression in fat tissues of a non-genetical obese model, VMH-lesioned rats. The ob mRNA was identified in both subcutaneous and mesenteric fat tissues in the control rats. In VMH-lesioned rats, the abundance of ob mRNA increased after the gain of body weight and marked expression was observed on 15th day after making VMH lesion. These data suggest that ob gene might be upregulated with fat accumulation even in non-genetically obese animals. (C) 1995 Academic Press, Inc.
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收藏
页码：469 / 475
页数：7
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