INHIBITION OF SPECIFIC PATHWAYS OF MYELOID CELL-DIFFERENTIATION BY AN ACTIVATED HOX-2.4 HOMEOBOX GENE

被引：0

作者：

BLATT, C ^{[1
]}

LOTEM, J ^{[1
]}

SACHS, L ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT MOLEC GENET & VIROL,IL-76100 REHOVOT,ISRAEL

来源：

CELL GROWTH & DIFFERENTIATION | 1992年 / 3卷 / 10期

关键词：

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Abnormal expression of homeobox genes is one of the abnormalities associated with the development of murine and human leukemia. Myeloid leukemic cells that can be induced to differentiate to mature cells by interleukin 6 were stably transfected with an activated Hox-2.4 homeobox gene. Expression of the Hox-2.4 gene in the transfected clones inhibited specific pathways of the myeloid differentiation program induced by interleukin 6. The expression of some genes associated with differentiation was almost completely blocked, and the expression of other genes was either partially inhibited or not affected. The results support the hypothesis that abnormal expression of Hox-2.4 may contribute to the development of leukemia by interfering with the differentiation program.

引用

页码：671 / 676

页数：6

共 46 条

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