The experimental potentials of the method for selection against provocative background (autoselection) in artificial populations of Drosophila melanogaster were analysed. The dynamics of adaptation of Drosophila population under increasing NaCl concentration in food was studied. It appeared that selection was successful in case of feedback between the selection pressure, mediated by alteration of salt concentration, and the rate of flies adaptation determined by the intensity of their reproduction. Within a short period of time, as the result of autoselection, the flies' ability for development with NaCl of up to 8% concentration in food was registered. It was shown that this resistance of flies to the salt was inherited within twelve successive generations.