SYNTHESIS OF 2-DIMETHYLAMINOIMIDAZOLE DERIVATIVES - A NEW ACCESS TO INDOLYL-IMIDAZOLE ALKALOIDS OF MARINE ORIGIN

被引：29
|
作者：
DALKAFOUKI, A [1 ]
ARDISSON, J [1 ]
KUNESCH, N [1 ]
LACOMBE, L [1 ]
POISSON, JE [1 ]
机构：
[1] COLL FRANCE,CNRS,CHIM INTERACT MOLEC LAB,F-75231 PARIS 05,FRANCE
来源：
TETRAHEDRON LETTERS | 1991年 / 32卷 / 39期
关键词：
INDOLYL-IMIDAZOLES; ALKALOIDS; APLYSINOPSIN; 2-DIMETHYLAMINOIMIDAZOLE; MARINE PRODUCTS;
D O I：
10.1016/S0040-4039(00)92376-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first preparation of 2-dimethylaminoimidazole 1a, a structural feature of several marine products was undertaken and its reactivity investigated. The synthesis of natural alkaloids 5 and 12b was achieved by direct coupling of the easily accessible oxidized 2-dimethylaminoimidazoles 7 and 8 with indole-3-carboxaldehyde and indole respectively, demonstrating the usefulness of this approach for other structurally related natural products.
引用
收藏
页码：5325 / 5328
页数：4
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