ALTERED LYMPHOCYTE PHENOTYPES AND PROLIFERATIVE RESPONSES IN CHIMPANZEES INFECTED WITH HEPATITIS-C VIRUS

被引：0
|
作者：
HOLZER, TJ
HEYNEN, CA
KENNEDY, MM
PETERSON, DA
机构：
来源：
JOURNAL OF MEDICAL PRIMATOLOGY | 1991年 / 20卷 / 06期
关键词：
HEPATITIS-C; NON-A; NON-B HEPATITIS; LEUKOCYTES SUBPOPULATIONS; LYMPHOCYTE PROLIFERATION; CHIMPANZEE; FLOW CYTOMETRY;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Peripheral blood mononuclear cells (MNC) from three chimpanzees infected with hepatitis C virus (HCV) and from two uninfected animals were analyzed by monoclonal antibody phenotyping using flow cytometry. Significant differences in numbers of MNC's expressing cluster designation (CD) phenotypes CD4, CD14, CD19, and CD45RA were found. Additionally, significant differences in MNC proliferation in response to mitogens were also found. This altered proliferative capacity and cellular phenotype profile may be important markers in studying the pathogenesis of chronic HCV disease.
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页码：295 / 301
页数：7
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