PYBOP AND PYBROP - 2 REAGENTS FOR THE DIFFICULT COUPLING OF THE ALPHA,ALPHA-DIALKYL AMINO-ACID, AIB

被引：208

作者：

FREROT, E ^{[1
]}

COSTE, J ^{[1
]}

PANTALONI, A ^{[1
]}

DUFOUR, MN ^{[1
]}

JOUIN, P ^{[1
]}

机构：

[1] CTR CNRS INSERM PHARMACOL ENDOCRINOL,F-34094 MONTPELLIER 5,FRANCE

来源：

TETRAHEDRON | 1991年 / 47卷 / 02期

关键词：

D O I：

10.1016/S0040-4020(01)80922-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The difficult coupling of alpha-aminoisobutyric acid (Aib) was carried out using PyBOP(R) and PyBroP in a comparative study with BOP and BroP. These reagents gave good results under simple conditions (one pot, r.t., 1 h). Coded amino acids could be coupled with Aib using PyBOP under standard conditions of peptide synthesis without racemization whereas the coupling of two Aib residues required PyBroP/DMAP. A fragment containing an Aib C-terminal could be coupled without epimerization of the penultimate residue.

引用

页码：259 / 270

页数：12

共 31 条

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