DECREASED MAP KINASE-ACTIVITY IN HUMAN GASTRIC ADENOCARCINOMA

被引：25
|
作者：
ATTEN, MJ
ATTAR, BM
HOLIAN, O
机构：
[1] COOK CTY HOSP,DEPT MED,DIV GASTROENTEROL,CHICAGO,IL 60612
[2] HEKTOEN INST MED RES,CHICAGO,IL 60612
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 212卷 / 03期
关键词：
D O I：
10.1006/bbrc.1995.2069
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the cellular signaling events involved in gastric cancer by examining the role of mitogen activated protein kinase (MAPK) in normal and transformed human gastric tissue. A significant loss in both MAPK abundance and activity was found in the membrane fractions of the adenocarcinomas when compared to the histologically normal gastric tissue, while no significant alteration in MAPK was seen in the cytosolic fractions from these two tissue types. These findings suggest that reduction in MAPK abundance and activity are associated with loss of normal growth control in human gastric adenocarcinoma. (C) 1995 Academic Press, Inc.
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页码：1001 / 1006
页数：6
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