MONOCLONAL-ANTIBODIES FOR IMMUNOINTERVENTION IN RHEUMATOID-ARTHRITIS

被引：0
作者：
HORNEFF, G
BURMESTER, GR
机构：
[1] CHARITE HUMBOLDT UNIV,MED KLIN & POLIKLIN 3,D-10117 BERLIN,GERMANY
[2] UNIV DUSSELDORF,ZENTRUM KINDERHEILKUNDE,D-40225 DUSSELDORF,GERMANY
来源：
ZEITSCHRIFT FUR RHEUMATOLOGIE | 1995年 / 54卷 / 02期
关键词：
RHEUMATOID ARTHRITIS; CYTOKINES; MONOCLONAL ANTIBODIES; CD4; CD5; CD7; CD25; TUMOR NECROSIS FACTOR; INTERLEUKIN-6;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rheumatoid arthritis is a chronic inflammatory disease mainly affecting the joints. The etiology is still unknown, but it shows several clinical and laboratory features of an autoimmune process. The conventional medical therapy consisting of a combination of analgetic and antiphlogistic agents with so called slow acting drugs is often not satisfactory and fails to persistently suppress disease activity. Therefore, therapeutic alternatives are necessary which are provided by a new generation of immunosuppressing agents including monoclonal antibodies. This paper will summarize some therapeutic approaches using monoclonal antibodies towards cell surface antigens or soluble mediators of inflammation for therapy of rheumatoid arthritis.
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页码：96 / 104
页数：9
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