PRESENCE OF IMMUNOREACTIVE PRO-OPIOMELANOCORTIN-DERIVED PEPTIDES AND CYTOKINES IN THE THYMUS OF AN ANURAN AMPHIBIAN (RANA-ESCULENTA)

被引：10
作者：
FRANCHINI, A
OTTAVIANI, E
FRANCESCHI, C
机构：
[1] UNIV MODENA,DEPT ANIM BIOL,I-41100 MODENA,ITALY
[2] UNIV MODENA,DEPT BIOMED SCI,GEN PATHOL SECT,I-41100 MODENA,ITALY
来源：
TISSUE & CELL | 1995年 / 27卷 / 03期
关键词：
THYMUS; RANA ESCULENTA; PRO-OPIOMELANOCORTIN-DERIVED PEPTIDES; CYTOKINES; IMMUNOCYTOCHEMISTRY;
D O I：
10.1016/S0040-8166(95)80046-8
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Pro-opiomelanocortin (POMG)-derived peptide [adrenocorticotropic hormone (ACTH), beta-endorphin, alpha-melanocyte-stimulating hormone (MSH)]- and cytokine (IL-1 alpha, IL-1 beta, IL-2, IL-6, TNF-alpha)-like molecules were demonstrated in PAS positive epithelial cells of the thymus of the anuran amphibian Rana esculenta by an immunocytochemical procedure. Three groups of PAS positive epithelial cells were identified in the subcapsular cortex, inner cortex and medulla, respectively. The cells containing ACTH-, alpha-MSH- and cytokine-like molecules were distributed in the cortex and those containing beta-endorphin-like molecules in the medulla and inner cortex. Thymic lymphocytes were always negative for POMC-derived peptides and cytokines. These results suggest that the neuroendocrine function of the thymus can be traced back to lower vertebrates.
引用
收藏
页码：263 / 267
页数：5
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