DESIGN AND SYNTHESIS OF DEOXYNUCLEIC GUANIDINE - A POLYCATION ANALOG OF DNA

被引：65

作者：

DEMPCY, RO

ALMARSSON, O

BRUICE, TC

机构：

[1] Department of Chemistry, University of California, Santa Barbara

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 17期

关键词：

ANTISENSE; ANTIGENE; HYBRID DUPLEX; TRIPLE HELIX;

D O I：

10.1073/pnas.91.17.7864

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The basic strategy is described for the connection of nucleosides by guanidinium (g) Linkers to provide the positively charged deoxgnucleic guanidine putative antigene agents. The synthetic procedures are provided for d(gT)(n). Molecular modeling of double-stranded [d(gT)(10).d(Ap)(10)] and the triple-helical hybrids [d(Tp)(10).d(Ap)(10).d(gT)(10)] and [d(gT)(10).d(Ap)(10).d(gT)(10)] suggest modes of interaction and anticipated structural features.

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页码：7864 / 7868

页数：5

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