NUCLEOTIDE-SEQUENCE THE ESCHERICHIA-COLI K12 HISTIDINE OPERON REVISITED

被引：4
|
作者：
JOVANOVIC, G [1 ]
KOSTIC, T [1 ]
JANKOVIC, M [1 ]
SAVIC, DJ [1 ]
机构：
[1] INST MOLEC GENET & GENET ENGN, YU-11001 BELGRADE, YUGOSLAVIA
来源：
JOURNAL OF MOLECULAR BIOLOGY | 1994年 / 239卷 / 03期
关键词：
ESCHERICHIA COLI K-12; HISTIDINE OPERON; NUCLEOTIDE SEQUENCE; POLYMORPHISM; POLA1 AND MUTD5 MUTATORS;
D O I：
10.1006/jmbi.1994.1384
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report on a significant difference between the published nucleotide sequence of the Escherichia coli K12 histidine operon and our sequencing results repeatedly obtained from a number of different E. coli K12 strains. The discrepancies include 39 base-pair changes and one addition located predominantly in the proximal portion of the operon. Our data also suggest that neutral and near-neutral mutations do not accumulate to a significant extent in the histidine operon of E. coli strains harbouring strong mutator alleles.
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收藏
页码：433 / 435
页数：3
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