ALTERED RESPONSES OF AORTIC SMOOTH-MUSCLE FROM SPRAGUE-DAWLEY RATS WITH SALT-INDUCED HYPERTENSION

被引：25

作者：

OBIEFUNA, PCM ^{[1
]}

EBEIGBE, AB ^{[1
]}

SOFOLA, OA ^{[1
]}

ALOAMAKA, CP ^{[1
]}

机构：

[1] UNIV BENIN,BENIN CITY,NIGERIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1991年 / 18卷 / 12期

关键词：

BLOOD PRESSURE; HYPERTENSION; NA-K ATPASE; SALT LOADING; VASCULAR SMOOTH MUSCLE;

D O I：

10.1111/j.1440-1681.1991.tb01400.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The contractile responses of aortic ring preparations from Sprague-Dawley rats made hypertensive by 6-week dietary salt loading were studied. The test and control diet contained 8.0 and 0.3% NaCl, respectively. Aortic rings from salt-loaded rats showed enhanced sensitivity to noradrenaline (NA) but not to serotonin. Contractile responses to CaCl2 in Ca-free NA-containing medium was significantly enhanced in salt-loaded rats, but was unchanged in K+-depolarised medium. K+-induced relaxation (a functional indicator of Na-K adenosine triphosphatase activity) was sensitive to 10-mu-mol/L ouabain and was significantly attenuated in aortic rings from salt-loaded rats. The results suggest that hypertension induced by salt-loading is associated with enhanced sensitivity to NA, increased Ca2+ entry through receptor-operated channels, and impairment of Na-K ATPase enzyme activity.

引用

页码：813 / 818

页数：6

共 24 条

[1] ABNORMAL VASCULAR FUNCTION AND MORPHOLOGY IN PRE-ECLAMPSIA - A STUDY OF ISOLATED RESISTANCE VESSELS [J].