HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING

被引:1074
作者
FERSHT, AR
SHI, JP
KNILLJONES, J
LOWE, DM
WILKINSON, AJ
BLOW, DM
BRICK, P
CARTER, P
WAYE, MMY
WINTER, G
机构
[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT PHYS,LONDON SW7 2AY,ENGLAND
[2] MRC CTR,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
关键词
D O I
10.1038/314235a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:235 / 238
页数:4
相关论文
共 23 条
[21]   SITE-DIRECTED MUTAGENESIS AS A PROBE OF ENZYME STRUCTURE AND CATALYSIS - TYROSYL-TRANSFER RNA-SYNTHETASE CYSTEINE-35 TO GLYCINE-35 MUTATION [J].
WILKINSON, AJ ;
FERSHT, AR ;
BLOW, DM ;
WINTER, G .
BIOCHEMISTRY, 1983, 22 (15) :3581-3586
[22]   A LARGE INCREASE IN ENZYME SUBSTRATE AFFINITY BY PROTEIN ENGINEERING [J].
WILKINSON, AJ ;
FERSHT, AR ;
BLOW, DM ;
CARTER, P ;
WINTER, G .
NATURE, 1984, 307 (5947) :187-188
[23]   REDESIGNING ENZYME STRUCTURE BY SITE-DIRECTED MUTAGENESIS - TYROSYL TRANSFER-RNA SYNTHETASE AND ATP BINDING [J].
WINTER, G ;
FERSHT, AR ;
WILKINSON, AJ ;
ZOLLER, M ;
SMITH, M .
NATURE, 1982, 299 (5885) :756-758