THE VARIED LIFE-STYLES OF INTRACELLULAR PATHOGENS WITHIN EUKARYOTIC VACUOLAR COMPARTMENTS

被引:100
作者
GARCIADELPORTILLO, F
FINLAY, BB
机构
[1] UNIV AUTONOMA MADRID,FAC BIOL,CTR BIOL MOLEC SEVERO OCHOA,DEPT MOLEC BIOL,E-28049 MADRID,SPAIN
[2] UNIV BRITISH COLUMBIA,BIOTECHNOL LAB,VANCOUVER,BC V6T 1Z3,CANADA
[3] UNIV BRITISH COLUMBIA,DEPT MICROBIOL & IMMUNOL,VANCOUVER,BC V6T 1Z3,CANADA
[4] UNIV BRITISH COLUMBIA,DEPT BIOCHEM & MOLEC BIOL,VANCOUVER,BC V6T 1Z3,CANADA
基金
英国医学研究理事会;
关键词
D O I
10.1016/S0966-842X(00)88982-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Many bacterial pathogens and eukaryotic parasites tan enter mammalian cells and live intracellularly inside membrane-bound vacuoles. The intravacuolar lifestyle of these pathogens plays a key role in pathogenesis. Understanding the molecular basis of the development of these specialized intracellular compartments is critical to understanding how these organisms cause disease.
引用
收藏
页码:373 / 380
页数:8
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