ELATOSIDE-A AND ELATOSIDE-B, POTENT INHIBITORS OF ETHANOL ABSORPTION IN RATS FROM THE BARK OF ARALIA-ELATA SEEM - THE STRUCTURE-ACTIVITY-RELATIONSHIPS OF OLEANOLIC ACID OLIGOGLYCOSIDES

被引：0

作者：

YOSHIKAWA, M

HARADA, E

MATSUDA, H

MURAKAMI, T

YAMAHARA, J

MURAKAMI, N

机构：

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1993年 / 41卷 / 11期

关键词：

ETHANOL ABSORPTION INHIBITORY EFFECT; STRUCTURE-ACTIVITY RELATIONSHIP; OLEANOLIC ACID OLIGOGLYCOSIDE; ELATOSIDE-A; ELATOSIDE-B; ARALIA-ELATA;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

By monitoring the inhibitory effect on ethanol absorption in rats, new active saponins named elatosides A and B were isolated from the bark of Aralia elata SEEM, together with elatosides C and D. The structures of elatosides A, B, C, and D were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of several oleanolic acid oligoglycosides on ethanol absorption have been examined and some structure-activity relationships have been found.

引用

页码：2069 / 2071

页数：3

共 2 条

[1] ELATOSIDE-E, A NEW HYPOGLYCEMIC PRINCIPLE FROM THE ROOT CORTEX OF ARALIA-ELATA SEEM - STRUCTURE-RELATED HYPOGLYCEMIC ACTIVITY OLEANOLIC ACID GLYCOSIDES
YOSHIKAWA, M
MATSUDA, H
HARADA, E
MURAKAMI, T
WARIISHI, N
MURAKAMI, N
YAMAHARA, J
CHEMICAL & PHARMACEUTICAL BULLETIN, 1994, 42 (06) : 1354 - 1356
[2] Bioactive saponins and glycosides .6. Elatosides A and B, potent inhibitors of ethanol absorption, from the bark of Aralia elata Seem (Araliaceae): The structure-requirement in oleanolic acid glucuronide-saponins for the inhibitory activity
Yoshikawa, M
Murakami, T
Harada, E
Murakami, N
Yamahara, J
Matsuda, H
CHEMICAL & PHARMACEUTICAL BULLETIN, 1996, 44 (10) : 1915 - 1922

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