BIOLOGIC AND IMMUNOLOGICAL GASTRIN ACTIVITY IN SERUM OF PATIENTS WITH GASTRINOMA - BIOASSAY OF GASTRIN ACTIVITY IN SERUM

被引：1

作者：

WALDUM, HL ^{[1
]}

MIGNON, M ^{[1
]}

SANDVIK, AK ^{[1
]}

BONFILS, S ^{[1
]}

机构：

[1] HOP BICHAT,F-75877 PARIS 18,FRANCE

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1992年 / 27卷 / 12期

关键词：

ACID; BIOASSAY; GASTRIN; HISTAMINE; IMMUNOASSAY; ZOLLINGER-ELLISON SYNDROME;

D O I：

10.3109/00365529209028135

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The biologic gastrin activity in serum from 14 patients with the Zollinger-Ellison syndrome was assessed by the stimulation of histamine release and acid secretion from the isolated vascularly perfused rat stomach and compared with the immunologic activity as determined by radioimmunoassay using an antibody directed towards the active site of the gastrin molecule. Biologic gastrin activity assessed by the stimulation of histamine release was more closely correlated to immunologic gastrin activity than biologic activity assessed by the stimulation of gastrin acid secretion. This study does not contradict the concept that gastrin stimulates acid secretion at least partly by releasing histamine and also shows that the immunologic gastrin activity determined with the help of an antibody directed towards the active site reflects biologic activity.

引用

页码：1039 / 1044

页数：6

共 44 条

[1]

ALLENDE HD, 1982, GASTROENTEROLOGY, V82, P1064

[2] PROGASTRIN IN SERUM FROM ZOLLINGER-ELLISON PATIENTS - AN INDICATOR OF MALIGNANCY [J].