HUMAN CHORIONIC PLATE ARTERIES LACK AN ENDOTHELIUM-DEPENDENT RELAXATION RESPONSE

被引：3
|
作者：
GRIGGS, KC [1 ]
MACKEY, KR [1 ]
MCLAUGHLIN, MK [1 ]
机构：
[1] UNIV VERMONT,COLL MED,DEPT PHYSIOL & BIOPHYS,BURLINGTON,VT 05405
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION PART B-HYPERTENSION IN PREGNANCY | 1991年 / 10卷 / 1-2期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.3109/10641959109079465
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study was designed to demonstrate that human chorionic plate arteries exhibit endothelium-dependent relaxation. Vessel ring segments (2mm long) were studied in a wire myograph system in which force and vessel dimensions were measured. The calcium ionophore A23187 (n = 10), or histamine (n = 2) was added to precontracted arteries in concentrations known to stimulate release of endothelium-derived relaxing factor(s) in umbilical vessels (10(-8) M-10(-6) M). A23187 did not cause relaxation of these arteries, while 10(-5) M histamine enhanced contraction. The vessels exhibited concentration-dependent relaxation in response to the addition of nitric oxide (n = 3), and relaxed completely upon addition of 10(-6) M sodium nitroprusside (n = 8), indicating a functional guanylate cyclase in the smooth muscle.
引用
收藏
页码：21 / 33
页数：13
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